Patents

Issued Patents

  • G.J. Shah, Pei Yuin Keng, R. Michael van Dam. Disposable world-to-chip interface for digital microfluidics. United States Patent 9,649,632. Issued May 16, 2017. Filed Jun 10, 2013. 
  • van Dam, R. Michael, Kim, Chang-Jin, Chen, Supin, Ding, Huijiang, Shah, Gaurav, Keng, Pei Yuin. Digital Microfluidic Platform for Radiochemistry. United States Patent 9,481,615. Issued Nov 1, 2016. Filed Oct 9, 2015.
  • Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen. Modular Radiochemistry Synthesis System. United States Patent 9,481,705. Issued Nov 1, 2016. Filed Nov 13, 2015.
  • van Dam, R. Michael, Kim, Chang-Jin, Chen, Supin, Ding, Huijiang, Shah, Gaurav, Keng, Pei Yuin. Digital Microfluidic Platform for Radiochemistry. United States Patent 9,193, 640. Issued Nov 14, 2015. Filed Mar 10, 2015.
  • Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen. Modular Radiochemistry Synthesis System. United States Patent 9,211,520. Issued Dec 15, 2015. Filed Dec 24, 2014.
  • van Dam, Michael, Liu, Kan, Shen, Clifton Kwang-Fu, Tseng, Hsian-Rong. Accurate and rapid micromixer for integrated microfluidic devices. United States Patent 9,138,700. Filed Jan 21, 2009.
  • van Dam, R. Michael, Kim, Chang-Jin, Chen, Supin, Ding, Huijiang, Shah, Gaurav, Keng, Pei Yuin. Digital Microfluidic Platform for Radiochemistry. United States Patent 9,005,544. Issued Apr 14, 2015. Filed Oct 15, 2009
  • Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen. Modular Radiochemistry Synthesis System. United States Patent 8,951,480. Issued Feb 10, 2015. Filed Aug 19, 2009.
Prior to UCLA:
  • Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael van Dam, Lawrence Diener, Sean Ford, Reza Miraghaie. Portable microfluidic radiosynthesis system for positron emission tomography biomarkers and program code. United States Patent 8,173,073. Issued May 8, 2012. Filed Oct 29, 2010. 
  • Elizarov, A.M., Ball, C.E., Zhang, J., Kolb, H., van Dam, R.M., Diener, L.T., Ford, S., Miraghaei, R. Microfluidic radiosynthesis system for positron emission tomography biomarkers. United States Patent 8,071,035. Issued Dec 6, 2011. Filed Apr 14, 2008. 
  • Elizarov, A.M., van Dam, R.M., Kolb, H.C., Heath, J.R. Microfluidic method and structure with an elastomeric gas-permeable gasket. United States Patent 7,862,000 B2. Issued Jan 4, 2011. Filed Feb 2, 2007. 
  • van Dam, R.M., Ball, C.E., Elizarov, A.M., Kolb, H.C. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography. United States Patent 7,829,032 B2. Issued Nov. 9, 2010. Filed Jan 23, 2007. 
  • Elizarov, A.M., Kolb, H.C., van Dam, R.M, Heath, J.R. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography. United States Patent 8,658,112. Issued Feb 25, 2014. Filed Sept 29, 2006. 
  • Elizarov, A.M., Kolb, H.C., van Dam, R.M, Heath, J.R. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography. United States Patent 8,075,851. Issued Dec. 13, 2011. Filed Sept 29, 2006. 
  • van Dam, R.M. and Elizarov, A.M. Method and apparatus for the mechanical actuation of valves in fluidic devices. United States Patent 8,480,053. Issued Jul 9, 2013. Filed Aug 30, 2006. 
  • Joseph M. DeSimon, Jason P. Rolland, Stephen R. Quake, Derek A. Schorzman, Jason Yarbrough, Michael van Dam. Photocurable perfluoropolyethers for use as novel materials in microfluidic devices. United States Patent 8,268,446. Issued Sept 18, 2012. Filed Sept 23, 2004.
  • van Dam, R.M., Brody, J.P., Shafee, R. and Quake, S.R. Non-metric tool for predicting gene relationships from expression data. United States Patent 6,947,846. Issued Sept 20, 2005. Filed Nov 5, 2002. 
  • van Dam, R.M., Unger, M.A., Quake, S.R. Combinatorial synthesis system. United States Patent 7,097,809. Issued Aug 29, 2006. Filed Apr 3, 2002. 
  • van Dam, R.M., Unger M.A. and Quake, S.R. Combinatorial synthesis system. United States Patent 6,508,988. Issued Jan 21, 2003. Filed Oct 3, 2000.

Patent Applications

  • Eric Schopf, Melissa Moore, R. Michael van Dam, Brandon Maraglia, Alexander Hsiao. Automated purification and formulation device for radiopharmaceutical compounds. U.S. Patent Applicatoin 15/698,350, filed Sept 7, 2017 [Priority data: 62/384,490, filed Sept 6, 2016]
  • Noel S. Ha, R. Michael van Dam. Method for efficient radiolabeling of biomolecules. PCT/US17/50214, filed Sept 6, 2017 [Priority data: 62/384079, filed Sept 6, 2016]
  • Philip H. Chao, R. Michael van Dam. Method for concentration and formulation of radiopharmaceuticals. PCT/US17/50236, filed Sept 6, 2017. [Priority data: 62/384,084, filed Sept 6, 2016]
  • R. Michael van Dam, Melissa D. Moore, B. Maraglia, D. Thompson. Self-shielded, benchtop radiochemistry system. PCT/US2015/034583, filed Jun 5, 2015. [Priority Data: 62/008,997, filed June 6, 2014] 
  • R. Michael van Dam, Melissa Moore, Kevin Quinn, Shane Claggett, Henry Herman, Mark Lazari. An automated, multi-pot high-pressure radio-synthesizer for production of PET tracers. WO/2014/160799 (PCT/US2014/031905), filed Mar 26, 2014. [Priority Data: 61/805,411 filed Mar 26, 2013]
  • Tseng, Hsian-Rong, Kamei, Kenichiro, Sun, Jing, Mischel, Paul S., Masterman-Smith, Michael D., Nathanson, David A., Huang, Tiffany, van Dam, Michael, Behrenbruch, Christian. Microfluidic Imaging Cytometry. WO/2009/100028 (PCT/US2009/032880), filed Feb 2, 2009. [Priority Data: 61/006,842 filed Feb 1, 2008] 
  • van Dam, R.M., Liu, Kan, Shen, Kwang-Fu Clifton, Tseng, Hsian-Rong. Method and device for microreactor pressure control. WO/2009/082535 (PCT/US2008/080200), filed Oct 16, 2008. [Priority Data: 60/960,844 filed Oct 16, 2007]
Prior to UCLA:
  • Elizarov, A.M., Kolb, H., van Dam, R.M., Heath, James R., Edgecombe, Brian, Farshad Motamedi, Stephen, Anthony, Giardello, Michael A. (2008). Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release. WO/2009/015048 (PCT/US2008/070558), filed July 18, 2008. [Priority Data: 60/950,976 filed July 20, 2007] 
  • van Dam, R.M., Elizarov, A.M., Heath, J.R. System and method for interfacing with a microfluidic chip. WO/2008/039875 (PCT/US2007/079601) filed Sept 26, 2007. [Priority Data: 60/847,993, filed Sept 28, 2006] 
  • van Dam, R.M., Quake, S.R. Combinatorial array for nucleic acid analysis. United States Patent Application 2005/0196785, filed Jan 5, 2005. 
  • Reese, M.O., van Dam, R.M., Scherer, A., Quake, S.R. Micro fabricated fountain pen apparatus and method for ultra high density biological arrays. WO/2003/053583 (PCT/US2002/035612) filed Nov 5, 2002. [Priority Data: 60/338,720 filed Nov 5, 2001; 60/364,202 filed Mar 14, 2002; 10/288,248 filed Nov 4, 2002] 
  • van Dam, R.M. and Quake, S.R. Combinatorial array for nucleic acid analysis. WO/2001/067369 (PCT/US2001/006967) filed Mar 5, 2001. [Priority Data: 60/186,765 filed Mar 3, 2000]