Patents

R. Michael van Dam, Jia Wang, Alejandra Rios. System and method for high-throughput radio thin layer chromatography analysis. United States Patent 12078625.  Issued Sept 3, 2024. Filed Apr 15, 2020.

R. Michael van Dam, Seunghyun Noel Ha, Jason Jones, Jimmy Ly, Stephen Liu and Shilin Cheung. Microscale device and method for purification of radiopharmaceuticals. United States Patent 11660571. Issued May 30, 2023. Filed Nov 14, 2017.

Noel S. Ha, Jimmy Ly, R. Michael van Dam. Volumetric micro-injector for capillary electrophoresis. United States Patent 11209390. Issued Dec 28, 2021. Filed Oct 6, 2017.

Jia Wang, R. Michael van Dam. Device and method for microscale chemical reactions. European Patent EP3523047. Issued Mar 24, 2021. Filed Oct 6, 2017. 

Jia Wang, R. Michael van Dam. Device and method for microscale chemical reactions. United States Patent US11383235. Issued Jul 12, 2022. Filed Oct 6, 2017. 

Eric Schopf, Melissa Moore, R. Michael van Dam, Brandon Maraglia, Alexander Hsiao. Automated purification and formulation device for radiopharmaceutical compounds. United States Patent 10,589,250. Issued Mar 17, 2020. Filed Sept 7, 2017. 

Philip H. Chao, R. Michael van Dam. Method for concentration and formulation of radiopharmaceuticals. European Patent EP 3510393. Issued Nov 4, 2020. Filed Sept 6, 2017.

R. Michael van Dam, Melissa Moore, B. Maraglia, D. Thompson. Self-shielded, benchtop radiochemistry system with a plurality of shielded carriers containing a disposable chip cassette. United States Patent 10,473,668. Issued Nov 12, 2019. Filed Jun 5, 2015. 

R. Michael van Dam, Melissa Moore, Kevin Quinn, Shane Claggett, Henry Herman, Mark Lazari. An automated, multi-pot high-pressure radio-synthesizer for production of PET tracers. United States Patent 10,081,005. Issued Sep 25, 2018. Filed Mar 26, 2013.

Maxim Sergeev, Federica Morgia, R. Michael van Dam, Mark Lazari. Metal oxide catalyzed radiofluorination. United States Patent 9,895,454. Issued Feb 2, 2018. Filed July 3, 2014.

G.J. Shah, Pei Yuin Keng, R. Michael van Dam. Disposable world-to-chip interface for digital microfluidics. United States Patent 9,649,632. Issued May 16, 2017. Filed Jun 10, 2013. 

van Dam, R. Michael, Kim, Chang-Jin, Chen, Supin, Ding, Huijiang, Shah, Gaurav, Keng, Pei Yuin. Digital Microfluidic Platform for Radiochemistry. United States Patent 9,481,615. Issued Nov 1, 2016. Filed Oct 9, 2015.

Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen. Modular Radiochemistry Synthesis System. United States Patent 9,481,705. Issued Nov 1, 2016. Filed Nov 13, 2015.

van Dam, R. Michael, Kim, Chang-Jin, Chen, Supin, Ding, Huijiang, Shah, Gaurav, Keng, Pei Yuin. Digital Microfluidic Platform for Radiochemistry. United States Patent 9,193, 640. Issued Nov 14, 2015. Filed Mar 10, 2015.

Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen. Modular Radiochemistry Synthesis System. United States Patent 9,211,520. Issued Dec 15, 2015. Filed Dec 24, 2014.

van Dam, Michael, Liu, Kan, Shen, Clifton Kwang-Fu, Tseng, Hsian-Rong. Accurate and rapid micromixer for integrated microfluidic devices. United States Patent 9,138,700. Filed Jan 21, 2009.

van Dam, R. Michael, Kim, Chang-Jin, Chen, Supin, Ding, Huijiang, Shah, Gaurav, Keng, Pei Yuin. Digital Microfluidic Platform for Radiochemistry. United States Patent 9,005,544. Issued Apr 14, 2015. Filed Oct 15, 2009

Nagichettiar Satyamurthy, Jorge R. Barrio, Bernard Amarasekera, R. Michael van Dam, Sebastian Olma, Dirk Williams, Mark Eddings, Clifton Kwang-Fu Shen. Modular Radiochemistry Synthesis System. United States Patent 8,951,480. Issued Feb 10, 2015. Filed Aug 19, 2009.

Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael van Dam, Lawrence Diener, Sean Ford, Reza Miraghaie. Portable microfluidic radiosynthesis system for positron emission tomography biomarkers and program code. United States Patent 8,173,073. Issued May 8, 2012. Filed Oct 29, 2010. 

Elizarov, A.M., Ball, C.E., Zhang, J., Kolb, H., van Dam, R.M., Diener, L.T., Ford, S., Miraghaei, R. Microfluidic radiosynthesis system for positron emission tomography biomarkers. United States Patent 8,071,035. Issued Dec 6, 2011. Filed Apr 14, 2008. 

Elizarov, A.M., van Dam, R.M., Kolb, H.C., Heath, J.R. Microfluidic method and structure with an elastomeric gas-permeable gasket. United States Patent 7,862,000 B2. Issued Jan 4, 2011. Filed Feb 2, 2007. 

van Dam, R.M., Ball, C.E., Elizarov, A.M., Kolb, H.C. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography. United States Patent 7,829,032 B2. Issued Nov. 9, 2010. Filed Jan 23, 2007. 

Elizarov, A.M., Kolb, H.C., van Dam, R.M, Heath, J.R. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography. United States Patent 8,658,112. Issued Feb 25, 2014. Filed Sept 29, 2006. 

Elizarov, A.M., Kolb, H.C., van Dam, R.M, Heath, J.R. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography. United States Patent 8,075,851. Issued Dec. 13, 2011. Filed Sept 29, 2006. 

van Dam, R.M. and Elizarov, A.M. Method and apparatus for the mechanical actuation of valves in fluidic devices. United States Patent 8,480,053. Issued Jul 9, 2013. Filed Aug 30, 2006. 

Joseph M. DeSimon, Jason P. Rolland, Stephen R. Quake, Derek A. Schorzman, Jason Yarbrough, Michael van Dam. Photocurable perfluoropolyethers for use as novel materials in microfluidic devices. United States Patent 8,268,446. Issued Sept 18, 2012. Filed Sept 23, 2004.

van Dam, R.M., Brody, J.P., Shafee, R. and Quake, S.R. Non-metric tool for predicting gene relationships from expression data. United States Patent 6,947,846. Issued Sept 20, 2005. Filed Nov 5, 2002. 

van Dam, R.M., Unger, M.A., Quake, S.R. Combinatorial synthesis system. United States Patent 7,097,809. Issued Aug 29, 2006. Filed Apr 3, 2002. 

van Dam, R.M., Unger M.A. and Quake, S.R. Combinatorial synthesis system. United States Patent 6,508,988. Issued Jan 21, 2003. Filed Oct 3, 2000.

R. Michael van Dam, Travis S. Holloway, Alejandra Rios, Chelsea Okoro. Systems and methods for the purification of radiopharmaceuticals using thin layer chromatography (TLC) plates. Patent Application PCT/US2021/057394, filed Oct 29, 2021. [Priority data: 63/110,964, filed Nov 6, 2020]

R. Michael van Dam, Jia Wang, Alejandra Rios, Philip Chao, Jason Jones. High-throughput radiochemistry platform. Patent Application PCT/US2020/045378, filed Aug 7, 2020. [Priority data: 62/884,352, filed Aug 8, 2019] 

Jia Wang, R. Michael van Dam. Ultra-compact, automated microdroplet radiosynthesizer. Patent Application PCT/US2020/034336, filed May 22, 2020. [Priority data: 62/851,207, filed May 22, 2019]

Noel S. Ha, R. Michael van Dam. Method for efficient radiolabeling of biomolecules. PCT/US2017/050214, filed Sept 6, 2017 [Priority data: 62/384079, filed Sept 6, 2016]

Tseng, Hsian-Rong, Kamei, Kenichiro, Sun, Jing, Mischel, Paul S., Masterman-Smith, Michael D., Nathanson, David A., Huang, Tiffany, van Dam, Michael, Behrenbruch, Christian. Microfluidic Imaging Cytometry. WO/2009/100028 (PCT/US2009/032880), filed Feb 2, 2009. [Priority Data: 61/006,842 filed Feb 1, 2008] 

van Dam, R.M., Liu, Kan, Shen, Kwang-Fu Clifton, Tseng, Hsian-Rong. Method and device for microreactor pressure control. WO/2009/082535 (PCT/US2008/080200), filed Oct 16, 2008. [Priority Data: 60/960,844 filed Oct 16, 2007]

Elizarov, A.M., Kolb, H., van Dam, R.M., Heath, James R., Edgecombe, Brian, Farshad Motamedi, Stephen, Anthony, Giardello, Michael A. (2008). Microfluidic radiosynthesis of a radiolabeled compound using electrochemical trapping and release. WO/2009/015048 (PCT/US2008/070558), filed July 18, 2008. [Priority Data: 60/950,976 filed July 20, 2007] 

van Dam, R.M., Elizarov, A.M., Heath, J.R. System and method for interfacing with a microfluidic chip. WO/2008/039875 (PCT/US2007/079601) filed Sept 26, 2007. [Priority Data: 60/847,993, filed Sept 28, 2006] 

van Dam, R.M., Quake, S.R. Combinatorial array for nucleic acid analysis. United States Patent Application 2005/0196785, filed Jan 5, 2005. 

Reese, M.O., van Dam, R.M., Scherer, A., Quake, S.R. Micro fabricated fountain pen apparatus and method for ultra high density biological arrays. WO/2003/053583 (PCT/US2002/035612) filed Nov 5, 2002. [Priority Data: 60/338,720 filed Nov 5, 2001; 60/364,202 filed Mar 14, 2002; 10/288,248 filed Nov 4, 2002] 

van Dam, R.M. and Quake, S.R. Combinatorial array for nucleic acid analysis. WO/2001/067369 (PCT/US2001/006967) filed Mar 5, 2001. [Priority Data: 60/186,765 filed Mar 3, 2000]