Tutorials

Significant figures

Propagation of significant figures when performing calculations

Measurement uncertainty and relation to significant figures

Uncertainty estimates (standard deviation, etc.)

Propagation of uncertainty when performing calculations

Good practices when presenting data

High-level overview

Part I: Molecular Shape

• Naming (functional groups, chains, branching)

Part II: Bonding

• Polarity

• Electrophiles, nucleophiles, formal charge

• Reactions and arrow pushing

Part III: Reactivity

• Reaction equations

• Equilibrium constant and free energy

• Energy diagrams and transition states

• Methods to reduce free energy

  • Temperature

  • Solvent effect (polarity)

 Overview of optical imaging methods and microscopy techniques

• Bright-field, phase-contrast, coherence tomography, diffuse optical tomography, luminescence microscopy and imaging, fluorescence microscopy, confocal microscopy, electron microscopy, scanning probe microscopy, mass spectrometry imaging, Cerenkov imaging, thermography

• Summary

Overview of magnetic resonance imaging (MRI) techniques

• MRI, Functional MRI, MR angiography, perfusion contrast imaging, diffusion contrast imaging, magnetic resonance spectroscopy, F-19 MRI

• Summary

Overview of ultrasound imaging techniques

• Ultrasound, contrast-enhanced ultrasound, photoacoustic imaging

• Summary

Overview of X-ray imaging techniques

• Projection radiography, dual-energy projection radiography, fluoroscopy (real-time imaging), X-ray computed tomography, contrast-enhanced CT, CT perfusion imaging

• Summary

Overview of radionuclide imaging techniques

• Scintigraphy (2D), SPECT, PET, PET/MRI

• Summary and comparison

Challenges and general approaches in 18F-radiochemistry

Overview of different labeling methods

• Nucleophilic fluorination

• Electrophilic fluorination

• Strategies for labeling biological molecules

Introduction to radiochemistry nomenclature, including recent recommendations from SRS

Basic principles and architecture of LabVIEW

Program flow structures ("for" loops, "while" loops, sequences, case structures, state machines)

Data structures (arrays, ...)

Linking to DAQ with myDAQ

Principles of photolithography

Mask design considerations (positive/negative resist, PDMS shrinkage)

Preparation of master molds

Preparing, molding, bonding, punching PDMS chips

Using PDMS as a mold material (why?, silanization)

Tips and tricks

HPLC operation

Scale (analytical vs semi-preparative)

Column types (reversed / normal phase)

Radio-HPLC

Understanding chromatograms

Injection and cleaning procedure

Elements of pneumatic and fluidic systems

• Tubing and manifolds

• Connectors

  • Types (barbed, compression, one-touch / quick-connect), material, sex

  • Categories (unions, elbows, adapters, Ys / Ts, plus, caps, N-way unions)

Fluidic connections

• Fluidic tubing (materials, sizes, tubing sleeves)

• Common fittings (1/4-28 flat, 10-32 coned, 6-32 coned, 6-40 flat, Luer-Lok, Omni-Fit)

• Common adapters

Pneumatic connections

• Pneumatic tubing (materials, sizes, limitations)

• Common fittings (one-touch, NPT sizes, other sizes: 10-32, M3, M5, barbed, Swage-Lok, solder joints)

• Common adapters

Conclusions and final consdierations

Introduction to common analytical methods

• Radio-TLC

• Radio-HPLC

Specify carefully what yield / efficiency you mean (start point, end point)

Radiochemical purity versus yield

What is Solidworks?

Online learning resources

Overall design strategy: 2D sketches converted to 3D

Constraint-driven design

2D sketch primitives (lines, rectangle, circles, arcs, construction lines)

3D conversion (extrude, cut, revolve around axis, hole wizard)

Additional tools (chamfers, fillets, arrays/grids, mirror, reference geometry)

There are many ways to draw any part -- choose a way that will make anticipated changes easy

Machinability

• Common machining operations after sawing (facing, milling, pocketing, drilling, tapping, reaming)

• Limitations (e.g. inside pockets generally cannot have perfectly square edges; holes can't bend internally)

Demonstration/exercise