Publications
Our publications can also be found in various online repositories:
Book Chapters
Jia Wang, R. Michael van Dam. Economical Production of Radiopharmaceuticals for Preclinical Imaging Using Microdroplet Radiochemistry. In: Biomedical Engineering Technologies. Methods in Molecular Biology, vol 2393. Eds. Ossandon M.R., Baker H., Rasooly A. pg 813-828. ISBN 978-1-0716-1802-8, New York, NY: Humana, 2022. (DOI Link)
Pei Yuin Keng, Maxim Sergeev, R. Michael van Dam. Advantages of Radiochemistry in Microliter Volumes. In Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. Eds. Kuge Y, Shiga T, Tamaki N. pg 93-111. ISBN 978-4-431-55892-7, Tokyo: Springer, 2016 (DOI Link)
Pei Yuin Keng, Melissa Esterby, R. Michael van Dam. Emerging Technologies for Decentralized Production of PET Tracers. In Positron Emission Tomography – Current Clinical and Research Aspects. Ed. Hsieh C-H. pg 153-182. ISBN 978-953-307-824-3, Rijeka, Croatia: InTech, 2012. (PDF Link)
Journal Papers
Yingqing Lu, Jeffrey Collins, Kuo-Shyan Lin, R. Michael van Dam. Scalable droplet-based radiosynthesis of [18F]fluorobenzyltri-phenylphosphonium cation ([18F]FBnTP) via a “numbering up” approach. Lab on a Chip 24: 728-737, 2024. DOI: 10.1039/D3LC01068F.
Yingqing Lu, Yingfang He, Roger Schibli, Linjing Mu, R. Michael van Dam. Proof-of-concept optimization of a copper-mediated 18F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation. Lab on a Chip 23: 4652-4663, 2023. DOI: 10.1039/D3LC00735A.
Jason Jones, Viviann Do, Yingqing Lu, R. Michael van Dam. Automated robotic platform for performing up to 64 droplet radiochemical reactions in a morning. Chemical Engineering Journal 468: 143524, 2023. DOI: 10.1016/j.cej.2023.143524
Travis S. Laferriere-Holloway, Alejandra Rios, R. Michael van Dam. Detrimental impact of aqueous mobile phases in 18F-labeled radiopharmaceutical analysis via radio-TLC. Analytical methods 15: 377-387, 2023. DOI: 10.1039/D2AY01206E.
Travis S. Laferriere-Holloway, Alejandra Rios, Yingqing Lu, Chelsea C. Okoro, R. Michael van Dam. A rapid and systematic approach for the optimization of radio thin-layer chromatography resolution. Journal of Chromatography A 1687: 463656, 2023. DOI: 10.1016/j.chroma.2022.463656.
Travis S. Laferriere-Holloway, Alejandra Rios, Giuseppe Carlucci, R. Michael van Dam. Rapid purification and formulation of radiopharmaceuticals via thin-layer chromatography. Molecules 27(23): 8178, 2022. DOI: 10.3390/molecules27238178. (Open Access - Journal Link)
Alejandra Rios, Travis S. Holloway, Philip H. Chao, Christian De Caro, Chelsea C. Okoro, and R. Michael van Dam. Microliter-scale reaction arrays for economical, high-throughput experimentation in radiochemistry. Scientific Reports 12: 10263, 2022. DOI: 10.1038/s41598-022-14022-2. (Open Access - Journal Link)
Yingqing Lu, Jia Wang, R. Michael van Dam*, Alexander Hsiao*. PHENYX: A flexible pipetting-based platform for automated microvolume radiochemistry. Chemical Engineering Journal 435(3): 134983, 2022. DOI: 10.1016/j.cej.2022.134983. (Journal Link)
Ksenia Lisova*, Jia Wang*, Tibor Jacob Hajagos, Yingqing Lu, Alexander Hsiao, Arkadij Elizarov, R. Michael van Dam. Economical droplet-based microfluidic production of [18F]FET and [18F]Florbetaben suitable for human use. Scientific Reports 11: 20636, 2021. (Open Access - Journal Link)
Alejandra Rios, Travis S. Holloway, Jia Wang, R. Michael van Dam. Optimization of Radiochemical Reactions using Droplet Arrays. J. Vis. Exp. 168: e62056, 2021. DOI: 10.3791/62056 (Open Access - Journal Link; Open Access - Video Link)
R. Michael van Dam and Arion F. Chatziioannou. Cerenkov luminescence imaging in the development and production of radiopharmaceuticals. Frontiers in Physics 9: 632056, 2021. DOI: 10.3389/fphy.2021.632056 (Open Access - Journal Link)
Ksenia Lisova, Jia Wang, Philip H. Chao, R. Michael van Dam. A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben. EJNMMI Radiopharmacy and Chemistry 5: 30, 2020. (Open Access - Journal Link)
Jia Wang, R. Michael van Dam. High-efficiency production of radiopharmaceuticals via droplet radiochemistry: a review of recent progress. Molecular Imaging 19: 1-21, 2020. https://doi.org/10.1177/1536012120973099 (Open Access - Journal Link)
Jia Wang, Philip H. Chao, Roger Slavik, R. Michael van Dam. Multi-GBq production of the radiotracer [18F]fallypride in a droplet microreactor. RSC Advances 10: 7828-7838, 2020. https://doi.org/10.1039/D0RA01212B (Open Access - Journal Link)
Jason Jones, Noel S. Ha, Alec G. Barajas, Arion F. Chatziioannou, R. Michael van Dam. Integration of high-resolution radiation detector for hybrid microchip electrophoresis (hybrid-MCE). Analytical Chemistry 92(4): 3483-3491, 2020. DOI: 10.1021/acs.analchem.9b04827 (Journal Link)
Jia Wang, Travis Holloway, Ksenia Lisova, R. Michael van Dam. Green and efficient synthesis of the radiopharmaceutical [18F]FDOPA using a microdroplet reactor. Reaction Chemistry & Engineering 5: 320-329, 2020. DOI: 10.1039/C9RE00354A (Journal Link) (PMC Link)
Jia Wang, Alejandra Rios, Ksenia Lisova, Roger Slavik, Arion F. Chatziioannou, R. Michael van Dam. High-throughput radio-TLC analysis. Nuclear Medicine and Biology 82-83: 41-48, 2020. (Journal Link)
Ksenia Lisova, Bao Ying Chen, Jia Wang, Kelly Mun-Ming Fong, Peter M. Clark, R. Michael van Dam. Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-([18F]fluoroethyl)-L-tyrosine ([18F]FET). EJNMMI Radiopharmacy and Chemistry 5: 1, 2020. (Journal Link - Open Access)
Pavitra Kannan, András Füredi, Sabina Dizdarevic, Thomas Wanek, Severin Mairinger, Jeffrey Collins, Theresa Falls, R. Michael van Dam, Divya Maheshwari, Jason T. Lee, Gergely Szakács, Oliver Langer. In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance. European Journal of Nuclear Medicine and Medical Imaging. 2019. DOI: 10.1007/s00259-019-04589-w (Journal Link)
Hee-Kwon Kim, Muhammad Rashed Javed, Supin Chen, Kirstin A. Zettlitz, Jeffrey Collins, Anna M. Wu, Chang-Jin “CJ” Kim, R. Michael van Dam, Pei Yuin Keng. On-demand radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on an electrowetting-on-dielectric microfluidic chip for 18F-labeling of protein. RSC Advances 9: 32175-32183 (2019). DOI: 10.1039/C9RA06158D . (Journal Link)
Jia Li, Noel S. Ha, Tingyi "Leo" Liu, R. Michael van Dam, Chang-Jin "CJ" Kim. Ionic-surfactant-mediated electro-dewetting for digital microfluidics. Nature 572: 507-510, 2019. DOI: 10.1038/s41586-019-1491-x. (Journal Link)
Alejandra Rios, Jia Wang, Philip H. Chao, R. Michael van Dam. A novel multi-reaction microdroplet platform for rapid radiochemistry optimization. RSC Advances 9: 20370-20374, 2019. DOI: 10.1039/C9RA03639C. (Journal Link)
Shi-He Liu, Yeahwa Hong, Stephen Markowiak, Robbi Sanchez, Justin Creeden, John Nemunaitis, Andrea Kalinoski, James Willey, Paul Erhardt, Jason Lee, Michael van Dam, F. Charles Brunicardi. BIRC5 is a target for molecular imaging and detection of human pancreatic cancer. Cancer Letters 457: 10-19, 2019. (DOI Link)
Jia Wang, Philip H. Chao, R. Michael van Dam. Ultra-compact, automated microdroplet radiosynthesizer. Lab on a Chip 19: 2415 - 2424, 2019. DOI: 10.1039/C9LC00438F. (Journal Link)
Christopher M. Waldmann, Andreea D. Stuparu, R. Michael van Dam, Roger Slavik. The search for an alternative to [68Ga]Ga-DOTA-TATE in neuroendocrine tumor theranostics: current state of 18F-labeled somatostatin analog development. Theranostics 9(5):1336-1347, 2019. DOI: 10.7150/thno.31806. (Journal Link)
Kirstin A. Zettlitz, Richard Tavaré, Wen-Ting K. Tsai, Reiko E. Yamada, Noel S. Ha, Jeffrey Collins, R. Michael van Dam, John M. Timmerman, Anna M. Wu. 18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B-cell lymphoma in human CD20 transgenic mice. EJNMMI 46(2): 489-500, 2018. DOI: 10.1007/s00259-018-4214-x. (Journal Link)
Eric Schopf, Christopher M. Waldmann, Jeffrey Collins, Chritopher Drake, Roger Slavik, R. Michael van Dam. Automating a positron-emission tomography (PET) radiotracer synthesis protocol for clinical production. Journal of Visualized Experiments 140: e58428, 2018. DOI: 10.3791/58428. (Open Access - Journal Link)
Philip H. Chao, Mark Lazari, Sebastian Hanet, Maruthi Kumar Narayanam, Jennifer M. Murphy, R. Michael van Dam. Automated concentration of [18F]fluoride into microliter volumes. Applied Radiation and Isotopes 141: 138-148, 2018. (Journal Link)
Ksenia Lisova, Maxim Sergeev, Susan Evans-Axelsson, Andreea D. Stuparu, Seval Beykan, Jeffrey Collins, Jason Jones, Michael Lassmann, Ken Herrmann, David Perrin, Jason T. Lee, Roger Slavik, R. Michael van Dam. Microscale radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: a potential PET tracer for clinical imaging of somatostatin receptors. Nuclear Medicine and Biology 61: 36-44, 2018. (Journal Link) (PMC Link)
Maxim Sergeev, Mark Lazari, Federica Morgia, Jeffrey Collins, Muhammad Rashed Javed, Olga Sergeeva, Jason Jones, Michael E. Phelps, Jason T. Lee, Pei Yuin Keng, R. Michael van Dam. Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography. Communications Chemistry 1: 10, 2018. DOI: 10.1038/s42004-018-0009-z. (Journal Link - open access PDF) (PMC Link)
Cesar Gonzalez, Andersson Sanchez, Jeffrey Collins, Ksenia Lisova, Jason T. Lee, R. Michael van Dam, M. Alejandro Barbieri, Cheppail Ramachandran and Stanislaw F. Wnuk. The 4-N-Acyl and 4-N-Alkyl Gemcitabine Analogues with Silicon-Fluoride-Acceptor: Application to 18F-Radiolabeling. European Journal of Medicinal Chemistry 148: 314-324, 2018. (ScienceDirect Link)
Jimmy Ly, Noel S. Ha, Shilin Cheung, R. Michael van Dam. Toward miniaturized analysis of chemical identity and purity of radiopharmaceuticals via microchip electrophoresis. Analytical and Bioanalytical Chemistry 410(9): 2423-2436, 2018. (Journal Link)
Noel S. Ha, Saman Sadeghi, R. Michael van Dam. Recent Progress Toward Microfluidic Quality Control Testing of Radiopharmaceuticals. Micromachines 8(11): 337, 2017. DOI: 10.3390/mi8110337. (Journal Link - open access PDF)
Jia Wang, Philip H. Chao, Sebastian Hanet, R. Michael van Dam. Performing multi-step chemical reactions in microliter-sized droplets by leveraging a simple passive transport mechanism. Lab Chip 17: 4342 – 4355, 2017. (Journal Link) (PMC Link)
Jeffrey Collins, Christopher M. Waldmann, Christopher Drake, Roger Slavik, Noel S. Ha, Maxim Sergeev, Mark Lazari, Bin Shen, Frederick T. Chin, Melissa Moore, Saman Sadeghi, Michael E. Phelps, Jennifer M. Murphy, R. Michael van Dam. Producing diverse probes for positron emission tomography with limited resources: Synthesis of 24 18F-labeled compounds with a single radiosynthesizer. PNAS 114(43): 11309-11314, 2017. (Journal Link)
Noel S. Ha, Jimmy Ly, Jason Jones, Shilin Cheung, R. Michael van Dam. Novel volumetric method for highly repeatable injection in microchip electrophoresis. Analytica Chimica Acta 985: 129-140, 2017. (Journal Link)
Philip H. Chao, Jeffrey Collins, Joseph P. Argus, Wei-Yu Tseng, Jason T. Lee, R. Michael van Dam. Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation. Lab on a Chip 17: 1802-1816, 2017. (Journal Link)
Jason T. Lee, Hanwen Zhang, Maxim A. Moroz, Yury Likar, Larissa Shenker, Nikita Sumzin, Jose Lobo, Juan Zurita, Jeffrey Collins, R. Michael van Dam, Vladimir Ponomarev. Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging. Molecular Imaging and Biology. DOI: 10.1007/s11307-016-0981-6, 2016. (Journal Link)
A. A. Dooraghi, L. Carroll, Jeffrey Collins, R. M. van Dam, A. F. Chatziioannou. ARAS: An Automated Radioactivity Aliquoting System for Dispensing Solutions Containing Positron-Emitting Radioisotopes. European Journal of Nuclear Medicine and Medical Imaging (EJNMMI) Research 6: 22, 2016.
Andrew J. Hoover, Mark Lazari, Hong Ren, Maruthi K. Narayanam, Jennifer M. Murphy, R. Michael van Dam, Jacob M. Hooker, and Tobias Ritter. A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging. Organometallics 35 (7): 1008–1014, 2016.
Mark Lazari, Jonathan Irribarren, Shuang Zhang, R. Michael van Dam. Understanding temperatures and pressures during short radiochemical reactions. Applied Radiation and Isotopes 108: 82-91, 2016.
Pei Yuin Keng and R. Michael van Dam. Digital microfluidics: A new paradigm for radiochemistry. Molecular Imaging 14: 579-594, 2015. (Journal Link - open access PDF)
Mark Lazari, Serge K. Lyashchenko, Eva M. Burnazi, Jason S. Lewis, R. Michael van Dam, Jennifer M. Murphy. Fully-automated synthesis of 16β-18F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer. Applied Radiation and Isotopes 103: 9 – 14, 2015.
Yi-Chun Chen, Kan Liu, Clifton Kwang-Fu Shen, R. Michael van Dam. On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size. J. Micromech. Microeng. 25: 084006, 2015.
Maxim E. Sergeev, Federica Morgia, Mark Lazari, Christopher Wang, R. Michael van Dam. Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium. J. Am. Chem. Soc. 137: 5686−5694, 2015.
M. Lazari, J. Collins, B. Shen, M. Farhoud, D. Yeh, B. Maraglia, F. T. Chin, D. A. Nathanson, M. Moore, and R. M. van Dam, “Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardware Modification,” J. Nucl. Med. Technol., vol. 42, no. 3, pp. 203–210, Sep. 2014.
S. Cheung, J. Ly, M. Lazari, S. Sadeghi, P. Y. Keng, and R. M. van Dam, “The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis,” Journal of Pharmaceutical and Biomedical Analysis, vol. 94, pp. 12–18, Jun. 2014.
G. J. Shah, U. Tata, and R. M. van Dam, “Automation and interfaces for chemistry and biochemistry in digital microfluidics,” Technology, vol. 02, no. 02, pp. 83–100, May 2014.
M. R. Javed, S. Chen, H.-K. Kim, L. Wei, J. Czernin, C.-J. “CJ” Kim, R. M. van Dam, and P. Y. Keng, “Efficient Radiosynthesis of 3′-Deoxy-3′-18F-Fluorothymidine Using Electrowetting-on-Dielectric Digital Microfluidic Chip,” J Nucl Med, vol. 55, no. 2, pp. 321–328, Feb. 2014.
W.-Y. Tseng and R. M. van Dam, “Compact microfluidic device for rapid concentration of PET tracers,” Lab Chip, vol. 14, no. 13, p. 2293, 2014.
M. R. Javed, S. Chen, J. Lei, J. Collins, M. Sergeev, H.-K. Kim, C.-J. Kim, R. M. van Dam, and P. Y. Keng, “High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging,” Chem. Commun., vol. 50, no. 10, pp. 1192–1194, 2014.
R. Ismail, J. Irribarren, M. R. Javed, A. Machness, M. van Dam, and P. Y. Keng, “Cationic imidazolium polymer monoliths for efficient solvent exchange, activation and fluorination on a continuous flow system,” RSC Advances, vol. 4, no. 48, pp. 25348–25356, 2014.
X. Ma, W.-Y. Tseng, M. Eddings, P. Y. Keng, and R. M. van Dam, “A microreactor with phase-change microvalves for batch chemical synthesis at high temperatures and pressures,” Lab Chip, vol. 14, no. 2, pp. 280–285, Dec. 2013.
S. Chen, M. R. Javed, H.-K. Kim, J. Lei, M. Lazari, G. J. Shah, M. van Dam, P. Y. Keng, and C.-J. Kim, “Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip,” Lab Chip 14: 902-910, 2014.
J. Ly, M. Masterman-Smith, R. Ramakrishnan, J. Sun, B. Kokubun, and R. M. van Dam, “Automated Reagent-Dispensing System for Microfluidic Cell Biology Assays,” Journal of Laboratory Automation, vol. 18, no. 6, pp. 530–541, Dec. 2013.
M. Lazari, K. M. Quinn, S. B. Claggett, J. Collins, G. J. Shah, H. E. Herman, B. Maraglia, M. E. Phelps, M. D. Moore, and R. M. van Dam, “ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers,” EJNMMI Res, vol. 3, no. 1, p. 52, Dec. 2013.
A. A. Dooraghi, P. Y. Keng, S. Chen, M. R. Javed, C.-J. “CJ” Kim, A. F. Chatziioannou, and R. M. van Dam, “Optimization of microfluidic PET tracer synthesis with Cerenkov imaging,” Analyst, vol. 138, no. 19, pp. 5654–5664, Aug. 2013.
H. Herman, G. Flores, K. Quinn, M. Eddings, S. Olma, M. D. Moore, H. Ding, K. P. Bobinski, M. Wang, D. Williams, D. Wiliams, C. K.-F. Shen, M. E. Phelps, and R. M. van Dam, “Plug-and-play modules for flexible radiosynthesis,” Applied Radiation and Isotopes, vol. 78, pp. 113–124, Aug. 2013.
B. Amarasekera, P. D. Marchis, K. P. Bobinski, C. G. Radu, J. Czernin, J. R. Barrio, and R. M. van Dam, “High-pressure, compact, modular radiosynthesizer for production of positron emitting biomarkers,” Applied Radiation and Isotopes, vol. 78, pp. 88–101, Aug. 2013.
S. B. Claggett, K. M. Quinn, M. Lazari, M. D. Moore, and R. M. van Dam, “Simplified programming and control of automated radiosynthesizers through unit operations,” EJNMMI Research, vol. 3, no. 1, p. 53, Jul. 2013.
G. J. Shah, H. Ding, S. Sadeghi, S. Chen, C.-J. “CJ” Kim, and R. M. van Dam, “On-demand droplet loading for automated organic chemistry on digital microfluidics,” Lab Chip, vol. 13, pp. 2785–2795, May 2013.
S. Sadeghi, V. Liang, S. Cheung, S. Woo, C. Wu, J. Ly, Y. Deng, M. Eddings, and R. M. van Dam, “Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers,” Applied Radiation and Isotopes, vol. 75, pp. 85–94, May 2013.
S. Sadeghi, H. Ding, G. J. Shah, S. Chen, P. Y. Keng, C.-J. “CJ” Kim, and R. M. van Dam, “On Chip Droplet Characterization: A Practical, High-Sensitivity Measurement of Droplet Impedance in Digital Microfluidics,” Anal. Chem., vol. 84, no. 4, pp. 1915–1923, Feb. 2012.
Y.-W. Yang, J. Hentschel, Y.-C. Chen, M. Lazari, H. Zeng, R. Michael van Dam, and Z. Guan, “‘Clicked’ fluoropolymer elastomers as robust materials for potential microfluidic device applications,” Journal of Materials Chemistry, vol. 22, no. 3, p. 1100, 2012.
P. Y. Keng, S. Chen, H. Ding, S. Sadeghi, G. J. Shah, A. Dooraghi, M. E. Phelps, N. Satyamurthy, A. F. Chatziioannou, C.-J. Kim, and R. M. van Dam, “Micro-chemical synthesis of molecular probes on an electronic microfluidic device,” PNAS, vol. 109, no. 3, pp. 690–695, 2012.
H. Ding, S. Sadeghi, G. J. Shah, S. Chen, P. Y. Keng, C. J. Kim, and M. van Dam, “Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips,” Lab on a Chip, vol. 12, pp. 3331–3340, 2012.
S. Sadeghi, W. A. MacKay, R. M. van Dam, and M. Thompson, “Algorithm for real-time detection of signal patterns using phase synchrony: an application to an electrode array,” Meas. Sci. Technol., vol. 22, no. 2, p. 025802, Feb. 2011.
K. Liu, E. J. Lepin, M.-W. Wang, F. Guo, W.-Y. Lin, Y.-C. Chen, S. J. Sirk, S. Olma, M. E. Phelps, X.-Z. Zhao, H.-R. Tseng, R. M. van Dam, A. M. Wu, and C. .-F. Shen, “Microfluidic-based 18F-Labeling of Biomolecules for Immuno-Positron Emission Tomography,” Mol. Imag., vol. 10, no. 3, pp. 168–176, 2011.
K. Liu, Y.-C. Chen, H.-R. Tseng, C. K.-F. Shen, and R. M. Dam, “Microfluidic device for robust generation of two-component liquid-in-air slugs with individually controlled composition,” Microfluid Nanofluid, vol. 9, no. 4–5, pp. 933–943, Apr. 2010.
J. Sun, M. D. Masterman-Smith, N. A. Graham, J. Jiao, J. Mottahedeh, D. R. Laks, M. Ohashi, J. DeJesus, K. Kamei, K.-B. Lee, H. Wang, Z. T. F. Yu, Y.-T. Lu, S. Hou, K. Li, M. Liu, N. Zhang, S. Wang, B. Angenieux, E. Panosyan, E. R. Samuels, J. Park, D. Williams, V. Konkankit, D. Nathanson, R. M. van Dam, M. E. Phelps, H. Wu, L. M. Liau, P. S. Mischel, J. A. Lazareff, H. I. Kornblum, W. H. Yong, T. G. Graeber, and H.-R. Tseng, “A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens,” Cancer Research, vol. 70, no. 15, pp. 6128 –6138, 2010.
J. S. Cho, R. Taschereau, S. Olma, K. Liu, Y.-C. Chen, C. K.-F. Shen, R. M. van Dam, and A. F. Chatziioannou, “Cerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip,” Physics in Medicine and Biology, vol. 54, no. 22, pp. 6757–6771, 2009. (PDF Link)
Prior to UCLA:
A. M. Elizarov, C. Meinhart, R. Miraghaie, R. M. van Dam, J. Huang, A. Daridon, J. R. Heath, and H. C. Kolb, “Flow optimization study of a batch microfluidics PET tracer synthesizing device,” Biomed Microdevices, vol. 13, no. 1, pp. 231–242, Nov. 2010.
A. M. Elizarov, R. M. van Dam, Y. S. Shin, H. C. Kolb, H. C. Padgett, D. Stout, J. Shu, J. Huang, A. Daridon, and J. R. Heath, “Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis,” J Nucl Med, vol. 51, no. 2, pp. 282–287, Feb. 2010.
G. Maltezos, E. Garcia, G. Hanrahan, F. A. Gomez, S. Vyawhare, R. M. van Dam, Y. Chen, and A. Scherer, “Design and fabrication of chemically robust three-dimensional microfluidic valves,” Lab Chip, vol. 7, no. 9, pp. 1209–1211, 2007.
J. P. Rolland, R. M. Van Dam, D. A. Schorzman, S. R. Quake, and J. M. DeSimone, “Solvent-Resistant Photocurable Liquid Fluoropolymers for Microfluidic Device Fabrication [corrected],” Journal of the American Chemical Society, vol. 126, no. 8, pp. 2322–2323, Mar. 2004.
M. O. Reese, R. M. van Dam, A. Scherer, and S. R. Quake, “Microfabricated Fountain Pens for High-Density DNA Arrays,” Genome Research, vol. 13, no. 10, pp. 2348–2352, Oct. 2003.
R. M. van Dam and S. R. Quake, “Gene Expression Analysis with Universal n-mer Arrays,” Genome Research, vol. 12, no. 1, pp. 145–152, Jan. 2002.
Editorials
Bernardes, E., Caravan, P., van Dam, R.M. et al. Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharmacy and Chemistry 7: 9 (2022). DOI: 10.1186/s41181-022-00162-3 (Journal Link - Open Access)
O.C. Kiss, P.J. Scott, M. Behe., ... M. van Dam, ... et al. Highlight selection of radiochemistry and radiopharmacy developments by editorial board. EJNMMI Radiopharmacy and Chemistry 8: 6 (2023). DOI: 10.1186/s41181-023-00192-5 (Journal Link - Open Access)
Conference Papers
Alejandra Rios, Travis S. Holloway, R. Michael van Dam. Radiopharmaceutical synthesis in microdroplets: From high-throughput synthesis optimization to clinical-scale production. Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). Pg. 1039 – 1040. Palm Springs, CA, USA, Oct 10 – 14, 2021.
Jia Wang, Philip H. Chao, R. Michael van Dam. Coffee cup-sized microdroplet radiosynthesizer. Proceedings of the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). pg. 546 – 547. Basel, Switzerland, Oct 27-31, 2019.
Alejandra Rios, Jia Wang, Philip Chao, R. Michael van Dam. High throughput microfluidic-based radiochemistry platform for development of PET tracers. Proceedings of the 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). pg. 1065 – 1067. Kaohsiung, Taiwan, Nov 11-15, 2018.
Philip H. Chao, Jia Wang, R. Michael van Dam. A fully automated radiosynthesis platform for scalable production and purification of PET tracers. Proceedings of the 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). pg. 1155 – 1158. Kaohsiung, Taiwan, Nov 11-15, 2018.
Jia Wang, R. Michael van Dam. Multi-step radiochemical reactions in microliter droplets leveraging surface tension-driven reagent transport via patterned wettability. Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), pg. 136-137, Dublin, Ireland, Oct. 9-13, 2016.
Noel S. Ha, Jimmy Ly, Shilin Cheung, R. Michael van Dam. Novel volumetric micro-injector for highly reproducible capillary electrophoresis. Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), pg. 1452-1453, Dublin, Ireland, Oct. 9-13, 2016.
M. Sergeev, M. Lazari, J. Collins, F. Morgia, M. R. Javed, P. Y. Keng, and R. M. van Dam, “Investigation of effect of reaction volume on specific activity in macro- and microscale fluorine-18 radiosynthesis,” in Proceedings of the 6th International Symposium on Microchemistry and Microsystems (ISMM), Singapore, 2014, pp. 77–78.
X. Ma, S. Chen, C.-J. C. Kim, and R. M. van Dam, “Towards on-chip chemical reaction monitoring by EWOD impedance measurement,” in Proceedings of the 27th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), San Francisco, CA, 2014, pp. 338–341.
X. Ma, S. Chen, C.-J. “CJ” Kim, and van Dam, R. Michael, “High-sensitivity and linearity electrical conductivity measurement of droplets in digital microfluidics,” in Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS), pg. 324-326, San Antonio, TX, 2014.
J. Ly, S. Cheung, and R. M. van Dam, “Micromolar detection of analytes via sub-300 nm UV absorbance in a PDMS microchip capillary electrophoresis device,” in Proceedings of the 6th International Symposium on Microchemistry and Microsystems (ISMM), Singapore, 2014, pp. 222–223.
S. Chen, A. Dooraghi, M. Lazari, R. M. van Dam, A. Chatziioannou, and C.-J. Kim, “On-chip product purification for complete microfluidic radiotracer synthesis,” in Proceedings of the 27th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), San Francisco, CA, 2014, pp. 284–287.
G. J. Shah, A. Saucedo, and R. M. van Dam, “Investigation of bursting of heated droplets for chemistry applications in digital microfluidics,” in Proceedings of the 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Freiburg, Germany, 2013, pp. 1230–1232.
W.-Y. Tseng, J. S. Cho, A. Chatziioannou, and R. M. van Dam, “Interdigitated evaporation chip for efficient solvent exchange in microchannels,” in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 2012, pp. 2008–2010.
G. J. Shah, J. Lei, S. Chen, C.-J. “CJ” Kim, P. Y. Keng, and R. M. Van Dam, “Automated injection from EWOD digital microfluidic chip into HPLC purification system,” in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 2012, pp. 356–358.
V. Liang, S. Woo, C. Wu, S. Sadeghi, and R. M. Van Dam, “Flow-through microfluidic digital impedance detection,” in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 2012, pp. 641–643.
H.-K. Kim, S. Chen, M. R. Javed, J. Lei, C.-J. Kim, P. Y. Keng, and R. M. van Dam, “Multi-step organic synthesis of four different molecular probes in digital microfluidic devices,” in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 2012, pp. 617–619.
R. Ismail, A. Machness, R. M. van Dam, and P. Y. Keng, “Flow-through solid phase [18F]fluorination on glass microfluidic chip,” in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 2012, pp. 629–631.
S. Chen, J. Lei, R. M. van Dam, P.-Y. Keng, and C.-J. “CJ” Kim, “Planar alumina purification of 18F-labeled radiotracer synthesis on EWOD chip for positron emission tomography (PET),” in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, 2012, pp. 1771–1773.
S. Chen, R. Javed, J. Lei, H.-K. Kim, G. Flores, R. M. van Dam, P. Y. Keng, and C.-J. Cim, “Synthesis of diverse tracers on EWOD microdevice for positron emission tomography (PET),” in Technical Digest of the Solid-State Sensor, Actuator and Microsystems Workshop, Hilton Head Island, SC, 2012, pp. 189–192.
G. J. Shah, H. Ding, S. Sadeghi, S. Chen, C.-J. Kim, and R. M. van Dam, “Milliliter-to-microliter platform for on-demand loading of aqueous and non-aqueous droplets to digital microfluidics,” in Proceedings of the 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011, pp. 1260–1263.
G. J. Shah, S. Sadeghi, H. Ding, S. Chen, and R. M. van Dam, “Impedance-based droplet volume and concentration measurement in digital microfluidics,” in Proceedings of the 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, WA, 2011, pp. 1308–1310.
W. C. Nelson, M. Yen, P. Y. Keng, R. M. van Dam, and C.-J. Kim, “High pressure EWOD digital microfluidics,” in Proceedings of the 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), Beijing, China, 2011, pp. 2932–2935.
H. Ding, S. Sadeghi, P. Y. Keng, S. Chen, G. J. Shah, C.-J. “CJ” Kim, and R. M. van Dam, “Accurate dispensing of volatile reagents on demand for EWOD chips,” in Proceedings of the 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, WA, 2011, pp. 227–229.
S. Chen, P. Y. Keng, R. M. van Dam, and C.-J. Kim, “Synthesis of 18F-labeled probes on EWOD platform for Positron Emission Tomography (PET) preclinical imaging,” in 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS), 2011, pp. 980–983.
W.-Y. Tseng, J. S. Cho, X. Ma, A. Kunihiro, A. Chatziioannou, and R. M. van Dam, “Toward reliable synthesis of radiotracers for positron emission tomography in PDMS microfluidic chips: Study and optimization of the [18F] fluoride drying process,” in Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Trade Show, Anaheim, CA, 2010, vol. 2, pp. 472–475.
W.-Y. Tseng, J. Cho, X. Ma, K. Mahal, A. Chatziioannou, and R. M. van Dam, “PDMS evaporation chip to concentrate [18F]fluoride for synthesis of PET tracers in microfluidics,” in Proceedings of the Fourteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, 2010, pp. 1010–1012.
S. Sadeghi, J. Ly, Y. Deng, and R. M. van Dam, “A robust platinum-based electrochemical micro flow cell for drying of [18F]fluoride for PET tracer synthesis,” in Proceedings of the Fourteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, 2010, pp. 318–320.
P. Y. Keng, S. Chen, H.-J. Ding, S. Sadeghi, M. E. Phelps, N. Satyamurthy, C.-J. Kim, and R. M. van Dam, “Optimization of radiosynthesis of molecular tracers in EWOD microfluidic chip,” in Proceedings of the Fourteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, 2010, pp. 668–670.
S. Chen, H. Ding, G. J. Shah, R. M. van Dam, and C.-J. Kim, “EWOD Microdevices for Synthesis of 18F-Labeled Tracers for Positron Emission Tomography (PET),” in Technical Digest of the Solid-State Sensor, Actuator and Microsystems Workshop, Hilton Head Island, SC, 2010, pp. 37–40.
S. Olma, K. Liu, Y.-C. Chen, H.-R. Tseng, R. M. van Dam, and C. K.-F. Shen, “Application of a Microfluidic Droplet Mixer for [18F]Fluorine Labeling of Biomolecules for Positron Emission Tomography,” in Proceedings of the Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Diego, CA, 2008, pp. 604–606.
K. Liu, C. Xia, C. K.-F. Shen, and R. M. van Dam, “Automated Delivery of Small Fluid Volumes Through Tubing to Microfluidic Chips,” in Proceedings of the Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Diego, CA, 2008, pp. 62–64.
K. Liu, Y.-C. Chen, H.-R. Tseng, C. K.-F. Shen, and R. M. van Dam, “Fluid-Parameter-Independent Microfluidic Device for Reliable Generation of Multi-Component Droplets,” in Proceedings of the Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Diego, CA, 2008, pp. 694–696.
J. S. Cho, A. Douraghy, S. Olma, K. Liu, Y. C. Chen, C. K. Shen, R. W. Silverman, R. M. van Dam, and A. F. Chatziioannou, “Čerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip,” in Proceedings of the IEEE Nuclear Science Symposium (NSS) Conference, 2008, pp. 4510–4515.
Prior to UCLA:
R. M. van Dam, A. M. Elizarov, C. E. Ball, C. K.-F. Shen, H. Padgett, H. Kolb, J. Rolland, L. Diener, D. Williams, B. Edgecombe, J. Jeffries, D. Stoianova, T. Stephen, F. Motamedi, and J. R. Heath, “Automated Microfluidic-Chip-Based Stand-Alone Instrument for the Synthesis of Radiopharmaceuticals on Human-Dose Scales,” in Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Santa Clara, CA, 2007, vol. 3, pp. 300–303.
J. P. Rolland, A. Elizarov, R. M. van Dam, J. Brewster, J. R. Heath, and J. M. DeSimone, “Chemically Robust Microfluidic Devices for Radiochemistry Platforms [authors corrected],” in Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Boston, MA, 2006, vol. 2, pp. 645–646.
A. M. Elizarov, R. M. van Dam, J. R. Heath, H. C. Kolb, J. Huang, and A. Daridon, “Microfluidic device with ‘coin-shaped reactor’ for radiopharmaceutical synthesis,” PMSE Prepr., vol. 94, pp. 858–859, 2006.
A. M. Elizarov, H. C. Kolb, R. M. van Dam, J. R. Heath, H. C. Padgett, J. Huang, and A. Daridon, “Coin-Shaped Reactor in Microfluidic Devices Used for Radiopharmaceutical Synthesis,” in Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Boston, MA, 2006, vol. 2, pp. 542–545.
J. P. Rolland, Z. Zhou, J. Y. Kelly, G. M. Denison, R. M. van Dam, E. C. Hagberg, K. R. Carter, S. R. Quake, and J. M. DeSimone, “Liquid Precursors for Applications in Microfluidics, Soft Lithography, and Fuel Cells,” PMSE Prepr., vol. 91, pp. 254–255, 2004.
J. P. Rolland, R. M. van Dam, E. C. Hagberg, K. R. Carter, S. R. Quake, and J. M. DeSimone, “Functional Perfluoropolyethers as novel Materials for Microfluidics and Soft Lithography,” Polym. Prepr., vol. 45, no. 2, pp. 106–107, 2004.
Theses
Travis S. Laferriere-Holloway, "Microfluidic Technologies for Positron Emission Tomography (PET) radiopharmaceutical microvolume production and analysis: How low can we go?" Ph.D. Thesis. Molecular & Medical Pharmacology, UCLA, 2022. [eScholarship link]
Alejandra Rios, "High-throughput technologies for the optimization of radiopharmaceuticals using microfluidics." Ph.D. Thesis. Physics and Biology in Medicine, UCLA, 2022. [eScholarship link]
Jason Jones, "Microfluidic Tools for Radiochemical Analysis and High-throughput Radiopharmaceutical Development". Ph.D. Thesis. Physics and Biology in Medicine, UCLA, 2021. [eScholarship link]
Ksenia Lisova, "Novel economical approaches for the fluorine-18 radiopharmaceuticals production via droplet radiochemistry". Ph.D. Thesis. Physics and Biology in Medicine, UCLA, 2021. [eScholarship link]
Jia Wang, "Radiochemistry in microdroplets: technologies and applications". Ph.D. Thesis. Bioengineering, UCLA, 2019. [eScholarship link]
Philip H. Chao, "Novel microfluidic technologies for the concentration of radionuclides and radiotracers for positron emission tomography". Ph.D. Thesis. Bioengineering, UCLA, 2019 [eScholarship link]
Noel S. Ha, "Microfluidics for the analysis and synthesis of PET tracers", Ph.D. Thesis. Bioengineering, UCLA, 2018 [eScholarship link]
Jimmy Ly, "Chemical purity analysis of PET radiotracers via microchip capillary electrophoresis". Ph.D. Thesis. Biomedical Engineering, UCLA, 2016. [eScholarship link]
Mark Lazari, "Thinking inside the “box”: Development and implementation of a novel automated radiosynthesizer for 18F-labeled positron emission tomography tracers". Ph.D. Thesis. Biomedical Enginering, University of California, Los Angeles, 2015. [eScholarship link]
Xiaoxiao Ma, "Expanding the capabilities of microfluidic systems for positron emission tomography (PET) tracer synthesis and analysis". Ph.D. Thesis. Molecular and Medical Pharmacology, University of California, Los Angeles, 2014. [eScholarship link]
Prior to UCLA:
R. Michael van Dam, "Solvent-resistant elastomeric microfluidic devices and applications", Ph.D. Thesis. Applied Physics, California Institute of Technology, 2006 [Respository link]
R. Michael van Dam, "Implementation of a free-space optical interconnect into the NUMAchine multiprocessor", M.A.Sc. Thesis. Electrical and Computer Engineering, University of Toronto, 1998 [Repository link]